Identification of Plasma Proteome Signatures Associated With Surgery Using SOMAscan.

ABSTRACT:

Objectives

To characterize the proteomic signature of surgery in older adults and association with postoperative outcomes.

Summary of background data

Circulating plasma proteins can reflect the physiological response to and clinical outcomes after surgery.

Methods

Blood plasma from older adults undergoing elective surgery was analyzed for 1305 proteins using SOMAscan. Surgery-associated proteins underwent Ingenuity Pathways Analysis. Selected surgery-associated proteins were independently validated using Luminex or enzyme-linked immunosorbent assay methods. Generalized linear models estimated correlations with postoperative outcomes.

Results

Plasma from a subcohort (n = 36) of the Successful Aging after Elective Surgery (SAGES) study was used for SOMAscan. Syst

SUBMITTER: Fong TG 

PROVIDER: S-EPMC6832727 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature