Mucosal Immunization with a pH-Responsive Nanoparticle Vaccine Induces Protective CD8⁺ Lung-Resident Memory T Cells.

ABSTRACT: Tissue-resident memory T cells (T_RM) patrol nonlymphoid organs and provide superior protection against pathogens that commonly infect mucosal and barrier tissues, such as the lungs, intestine, liver, and skin. Thus, there is a need for vaccine technologies that can induce a robust, protective T_RM response in these tissues. Nanoparticle (NP) vaccines offer important advantages over conventional vaccines; however, there has been minimal investigation into the design of NP-based vaccines for eliciting T_RM responses. Here, we describe a pH-responsive polymeric nanoparticle vaccine for generating antigen-specific CD8⁺ T_RM cells in the lungs. With a single intranasal dose, the NP vaccine elicited airway- and lung-resident CD8⁺ T

SUBMITTER: Knight FC 

PROVIDER: S-EPMC6832804 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature