Long-Term Outcome and Rejection After Allogeneic Uterus Transplantation in Cynomolgus Macaques.

ABSTRACT: Uterus transplantation (UTx) is an option for women with uterine factor infertility to have a child, but is still in the experimental stage. Therefore, allogeneic animal models of UTx are required for resolution of clinical issues. In this study, long-term outcomes were evaluated in four recipients (cases 1-4) after allogeneic UTx in cynomolgus macaques. Immunosuppression with antithymocyte globulin induction and a triple maintenance regimen was used. Postoperative ultrasonography and biopsy of the transplanted uterus and immunoserological examinations were performed. All four recipients survived for >3 months after surgery, but continuous menstruation did not resume, although temporary menstruation occurred (cases 1 and 2). All animals were euthanized due to irreversible rejection and no

SUBMITTER: Kisu I 

PROVIDER: S-EPMC6833021 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature