Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus.

ABSTRACT: Vaccines against classical swine fever have proven very effective in protecting pigs from this deadly disease. However, little is known about how vaccination impacts the selective pressures acting on the classical swine fever virus (CSFV). Here we use high-throughput sequencing of viral genomes to investigate evolutionary changes in virus populations following the challenge of naïve and vaccinated pigs with the highly virulent CSFV strain "Koslov". The challenge inoculum contained an ensemble of closely related viral sequences, with three major haplotypes being present, termed A, B, and C. After the challenge, the viral haplotype A was preferentially located within the tonsils of naïve animals but was highly prevalent in the sera of all vaccinated animals. We find that the viral population

SUBMITTER: Fahnoe U 

PROVIDER: S-EPMC6833067 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature