Identification of single nucleotide polymorphisms of PIK3R1 and DUSP1 genes and their genetic associations with milk production traits in dairy cows.

ABSTRACT:

Background

Previously, phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) and dual specificity phosphatase 1 (DUSP1) were identified as promising candidate genes for milk production traits due to their being differentially expressed between the dry period and the peak of lactation in livers of dairy cows. Hence, in this study, the single nucleotide polymorphisms (SNPs) of PIK3R1 and DUSP1 genes were identified and their genetic associations with milk yield, fat yield, fat percentage, protein yield, and protein percentage, were investigated using 1067 Chinese Holstein cows from 40 sire families.

Results

By re-sequencing the entire coding region and 2000 bp of the 5' and 3' flanking regions of the two genes, one SNP in the 5' untranslated regio

SUBMITTER: Han B 

PROVIDER: S-EPMC6833155 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature