Impact of parturition on maternal cardiovascular and neuronal integrity in a high risk cohort - a prospective cohort study.

ABSTRACT:

Background

To better understand the profound multisystem changes in maternal physiology triggered by parturition, in particular in the underexplored neuronal system, by deploying a panel of pre- vs post-delivery maternal serum biomarkers, most notably the neuronal cytoskeleton constituent neurofilament light chain (NfL). This promising fluid biomarker is not only increasingly applied to investigate disease progression in numerous brain diseases, particularly in proteopathies, but also in detection of traumatic brain injury or monitoring neuroaxonal injury after ischemic stroke.

Methods

The study was nested within a prospective cohort study of pregnant women at risk of developing preeclampsia at the University Hospital of Basel. Paired ante- and postpartum levels of progester

SUBMITTER: Evers KS 

PROVIDER: S-EPMC6833198 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature