The prognostic association of SPAG5 gene expression in breast cancer patients with systematic therapy.

ABSTRACT: BACKGROUND:Despite much effort on the treatment of breast cancer over the decades, a great uncertainty regarding the appropriate molecular biomarkers and optimal therapeutic strategy still exists. This research was performed to analyze the association of SPAG5 gene expression with clinicopathological factors and survival outcomes. METHODS:We used a breast cancer database including 5667 patients with a mean follow-up of 69 months. Kaplan-Meier survival analyses for relapse free survival (RFS), overall survival (OS), and distant metastasis-free survival (DMFS) were performed. In addition, ROC analysis was performed to validate SPAG5 as a prognostic candidate gene. RESULTS:Mean SPAG5 expression value was significantly higher with some clinicopathological factors that resulted in tumor promoti

SUBMITTER: Zhu C 

PROVIDER: S-EPMC6833211 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature