Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts.

ABSTRACT: Condensin is an essential component of chromosome dynamics, including mitotic chromosome condensation and segregation, DNA repair, and development. Genome-wide localization of condensin is known to correlate with transcriptional activity. The functional relationship between condensin accumulation and transcription sites remains unclear, however. By constructing the auxin-inducible degron strain of condensin, herein we demonstrate that condensin does not affect transcription itself. Instead, RNA processing at transcriptional termination appears to define condensin accumulation sites during mitosis, in the fission yeast Schizosaccharomyces pombe. Combining the auxin-degron strain with the nda3 β-tubulin cold-sensitive (cs) mutant enabled us to inactivate condensin in mitotically arrested cel

SUBMITTER: Nakazawa N 

PROVIDER: S-EPMC6833218 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature