Identifying the start of a platelet aggregate by the shear rate and the cell-depleted layer.

ABSTRACT: Computer simulations were performed to study the transport of red blood cells and platelets in high shear flows, mimicking earlier published in vitro experiments in microfluidic devices with high affinity for platelet aggregate formation. The goal is to understand and predict where thrombus formation starts. Additionally, the need of cell-based modelling in these microfluidic devices is demonstrated by comparing our results with macroscopic models, wherein blood is modelled as a continuous fluid. Hemocell, a cell-based blood flow simulation framework is used to investigate the transport physics in the microfluidic devices. The simulations show an enlarged cell-depleted layer at the site where a platelet aggregate forms in the experiments. In this enlarged cell-depleted layer, the probabili

SUBMITTER: van Rooij BJM 

PROVIDER: S-EPMC6833312 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature