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Andrastone A From the Deep-Sea-Derived Fungus Penicillium allii-sativi Acts as an Inducer of Caspase and RXRα-Dependent Apoptosis.

ABSTRACT: Two new (1, 2) and one known (3) meroterpenoids were isolated from the deep-sea-derived fungus Penicillium allii-sativi. The relative structures of new compounds were determined on the basis of an extensive analysis of the NMR and MS data, and the absolute configurations were established by ECD calculations. Andrastone A (1) is a rare andrastin bearing an unusual cyclopentan-1,3-dione. It shows a selectively antiproliferative effect against HepG2 tumor cells with an IC₅₀ value of 7.8 μM. Mechanism study showed that apoptosis via Caspase and RXRα pathways are responsible for the inhibitory effect.

SUBMITTER: Xie CL

PROVIDER: S-EPMC6833938 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Andrastone A From the Deep-Sea-Derived Fungus Penicillium allii-sativi Acts as an Inducer of Caspase and RXRα-Dependent Apoptosis.

Xie Chun-Lan CL Xia Jin-Mei JM Lin Ting T Lin Ying-Jie YJ Lin Yu-Kun YK Xia Man-Li ML Chen Hai-Feng HF Luo Zhu-Hua ZH Shao Zong-Ze ZZ Yang Xian-Wen XW

Frontiers in chemistry 20191030

Two new (1, 2) and one known (3) meroterpenoids were isolated from the deep-sea-derived fungus Penicillium allii-sativi. The relative structures of new compounds were determined on the basis of an extensive analysis of the NMR and MS data, and the absolute configurations were established by ECD calculations. Andrastone A (1) is a rare andrastin bearing an unusual cyclopentan-1,3-dione. It shows a selectively antiproliferative effect against HepG2 tumor cells wi ...[more]

PMID: 31737594

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