Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5_p15.33 TERT-CLPTM1Ll Region.

ABSTRACT:

Introduction

Inherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study on the largest, to date, set of European-descent never-smokers with lung cancer.

Methods

We conducted a two-phase (discovery and replication) genome-wide association study in never-smokers of European descent. We further augmented the sample by performing a meta-analysis with never-smokers from the recent OncoArray study, which resulted in a total of 3636 cases and 6295 controls. We also compare our findings with those in smokers with lung cancer.

Results</

SUBMITTER: Hung RJ 

PROVIDER: S-EPMC6833942 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature