Dataset Information

Impact of Zika Virus Emergence in French Guiana: A Large General Population Seroprevalence Survey.

ABSTRACT:

Background

Since the identification of Zika virus (ZIKV) in Brazil in May 2015, the virus has spread throughout the Americas. However, ZIKV burden in the general population in affected countries remains unknown.

Methods

We conducted a general population survey in the different communities of French Guiana through individual interviews and serologic survey during June-October 2017. All serum samples were tested for anti-ZIKV immunoglobulin G antibodies using a recombinant antigen-based SGERPAxMap microsphere immunoassay, and some of them were further evaluated through anti-ZIKV microneutralization tests.

Results

The overall seroprevalence was estimated at 23.3% (95% confidence interval [CI], 20.9%-25.9%) among 2697 participants, varying from 0% to 45.6% according to municipalities. ZIKV circulated in a large majority of French Guiana but not in the most isolated forest areas. The proportion of reported symptomatic Zika infection was estimated at 25.5% (95% CI, 20.3%-31.4%) in individuals who tested positive for ZIKV.

Conclusions

This study described a large-scale representative ZIKV seroprevalence study in South America from the recent 2015-2016 Zika epidemic. Our findings reveal that the majority of the population remains susceptible to ZIKV, which could potentially allow future reintroductions of the virus.

SUBMITTER: Flamand C

PROVIDER: S-EPMC6834069 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Publications

Impact of Zika Virus Emergence in French Guiana: A Large General Population Seroprevalence Survey.

Flamand Claude C Bailly Sarah S Fritzell Camille C Berthelot Léna L Vanhomwegen Jessica J Salje Henrik H Paireau Juliette J Matheus Séverine S Enfissi Antoine A Fernandes-Pellerin Sandrine S Djossou Félix F Linares Sébastien S Carod Jean-François JF Kazanji Mirdad M Manuguerra Jean-Claude JC Cauchemez Simon S Rousset Dominique D

The Journal of infectious diseases 20191101 12

<h4>Background</h4>Since the identification of Zika virus (ZIKV) in Brazil in May 2015, the virus has spread throughout the Americas. However, ZIKV burden in the general population in affected countries remains unknown.<h4>Methods</h4>We conducted a general population survey in the different communities of French Guiana through individual interviews and serologic survey during June-October 2017. All serum samples were tested for anti-ZIKV immunoglobulin G antibodies using a recombinant antigen-b ...[more]

PMID: 31418012

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Project description:BackgroundUrban arboviruses pose a significant global burden, particularly in tropical regions like Brazil. São Sebastião, a lower-middle-class urban area just 26 km from the Brazilian capital, is an endemic area for dengue. However, asymptomatic cases may obscure the actual extent of the disease. In this study, we measured the seroprevalence of dengue, Zika virus, and chikungunya, and compared these findings with surveillance data.MethodsA cross-sectional study was conducted involving 1,535 households. ELISA serological tests were performed to detect IgM and IgG antibodies against dengue, Zika virus, and chikungunya. History of previous exposure to arboviruses, data on age, gender, and education level were collected through a questionnaire. Participants who tested positive for IgM and/or IgG were classified as soropositive. Statistical analyses included tests for normality, associations, mean comparisons, and correlations. Positive serological results were compared with cases captured by local epidemiological surveillance.ResultsThe study included 1,405 individuals, divided into two groups related to pre-pandemic and pandemic COVID-19 phases. Among participants, 0.7% to 28.8% self-reported history of dengue, Zika, or chikungunya. However, the estimated overall seroprevalence was 64.3% (95% CI: 61.8-66.7) for dengue virus, 51.4% (95% CI: 48.8-53.9) for Zika virus, and 5.4% (95% CI: 4.4-6.7) for chikungunya virus. Multiple arboviruses were noted at 4.0% (95% CI: 3.1-5.1). Advancing age and lower education were associated with higher exposure to arboviruses (p < 0.05). The estimated number of urban arboviral infections was 84 times higher than reported cases.ConclusionsThe large gap between seroprevalence estimates and cases captured by epidemiological surveillance suggests a silent circulation of arboviruses, highlighting the need for comprehensive serological surveys in endemic regions. Addressing these discrepancies is crucial for effective resource allocation and implementation of public health interventions.

Dataset Information

Impact of Zika Virus Emergence in French Guiana: A Large General Population Seroprevalence Survey.

Background

Methods

Results

Conclusions

Publications

Impact of Zika Virus Emergence in French Guiana: A Large General Population Seroprevalence Survey.

Similar Datasets

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