Uncovering and characterizing splice variants associated with survival in lung cancer patients.

ABSTRACT: Splice variants have been shown to play an important role in tumor initiation and progression and can serve as novel cancer biomarkers. However, the clinical importance of individual splice variants and the mechanisms by which they can perturb cellular functions are still poorly understood. To address these issues, we developed an efficient and robust computational method to: (1) identify splice variants that are associated with patient survival in a statistically significant manner; and (2) predict rewired protein-protein interactions that may result from altered patterns of expression of such variants. We applied our method to the lung adenocarcinoma dataset from TCGA and identified splice variants that are significantly associated with patient survival and can alter protein-protein inte

SUBMITTER: West S 

PROVIDER: S-EPMC6834284 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature