Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence.

ABSTRACT: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research and drug discovery. Clinical implications of PPAR agonists span across a wide range of health conditions, including metabolic diseases, chronic inflammatory diseases, infections, autoimmune diseases, neurological and psychiatric disorders, and malignancies. In this review we aim to consolidate existing clinical evidence of PPAR modulators, highlighting their clinical prospects and challenges. Findings from clinical trials revealed that different agonists of the same PPAR subtype could present di

SUBMITTER: Cheng HS 

PROVIDER: S-EPMC6834327 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature