Understanding allergic multimorbidity within the non-eosinophilic interactome.

ABSTRACT:

Background

The mechanisms explaining multimorbidity between asthma, dermatitis and rhinitis (allergic multimorbidity) are not well known. We investigated these mechanisms and their specificity in distinct cell types by means of an interactome-based analysis of expression data.

Methods

Genes associated to the diseases were identified using data mining approaches, and their multimorbidity mechanisms in distinct cell types were characterized by means of an in silico analysis of the topology of the human interactome.

Results

We characterized specific pathomechanisms for multimorbidities between asthma, dermatitis and rhinitis for distinct emergent non-eosinophilic cell types. We observed differential roles for cytokine signaling, TLR-mediated signaling and metabolic pathw

SUBMITTER: Aguilar D 

PROVIDER: S-EPMC6834334 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature