Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer's disease spectrum.

ABSTRACT:

Background

Narrative discourse (ND) refers to one's ability to verbally reproduce a sequence of temporally and logically-linked events. Impairments in ND may occur in subjects with Amnestic Mild Cognitive Impairment (aMCI) and Alzheimer's Disease (AD), but correlates across this function, neuroimaging and cerebrospinal fluid (CSF) AD biomarkers remain understudied.

Objectives

We sought to measure correlates among ND, Diffusion Tensor Imaging (DTI) indexes and AD CSF biomarkers in patients within the AD spectrum.

Results

Groups differed in narrative production (NProd) and comprehension. aMCI and AD presented poorer inference abilities than controls. AD subjects were more impaired than controls and aMCI regarding WB (p<0.01). ROIs DTI assessment distinguished the three

SUBMITTER: Drummond C 

PROVIDER: S-EPMC6834410 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature