Dysfunctional interactions between the default mode network and the dorsal attention network in subtypes of amnestic mild cognitive impairment.

ABSTRACT: An anticorrelated relationship in the spontaneous fluctuations between the default mode network (DMN) and dorsal attention network (DAN) is a robust feature of intrinsic brain organization in healthy individuals. Prior studies have reported a decreased anticorrelation between the DMN and the DAN in Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, it is unclear how this anticorrelation changes as MCI progresses to AD. We hypothesized that dysfunctional connectivity between the DMN and DAN may reflect the gradual decline from MCI to AD. To test this hypothesis, we investigated alterations in functional connectivity between the DMN and DAN in subtypes of amnestic MCI (aMCI) by comparing with the same functional pattern in healthy elderly individuals and patients with AD.

SUBMITTER: Wang J 

PROVIDER: S-EPMC6834429 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature