Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway.

ABSTRACT: Amyloid-β (Aβ) is considered partially responsible for cognitive dysfunction in Alzheimer's disease (AD). Resveratrol is known as an anti-neurotoxicity potential natural product, however low blood-brain-barrier (BBB) permissibility and low oral-bioavailability (OB) are the main limitations on its clinical potential. In this study, we illustrated that Pterostilbene (PTS), a kind of resveratrol analog which showed higher scores on BBB and OB, could overcome Aβ-induced neurotoxicity in vitro and in vivo. In silico simulation indicated PTS binding with PDE4A may contribute to its anti-apoptosis and anti-neurotoxicity effects. Behavioral tests further confirmed PTS' potential of overcoming memory deficits in APP/PS1 mice (AD model). Interestingly, PTS also rescued the reduc

SUBMITTER: Meng J 

PROVIDER: S-EPMC6834512 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature