ShuTu: Open-Source Software for Efficient and Accurate Reconstruction of Dendritic Morphology.

ABSTRACT: Neurons perform computations by integrating inputs from thousands of synapses-mostly in the dendritic tree-to drive action potential firing in the axon. One fruitful approach to studying this process is to record from neurons using patch-clamp electrodes, fill the recorded neurons with a substance that allows subsequent staining, reconstruct the three-dimensional architectures of the dendrites, and use the resulting functional and structural data to develop computer models of dendritic integration. Accurately producing quantitative reconstructions of dendrites is typically a tedious process taking many hours of manual inspection and measurement. Here we present ShuTu, a new software package that facilitates accurate and efficient reconstruction of dendrites imaged using bright-field micros

SUBMITTER: Jin DZ 

PROVIDER: S-EPMC6834530 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature