Impaired Antibody-Independent Immune Response of B Cells in Patients With Acute Dengue Infection.

ABSTRACT: Dengue is a mosquito-borne viral disease caused by dengue virus (DENV). The disease is endemic to more than 100 countries with 390 million dengue infections per year. Humoral immune responses during primary and secondary DENV infections are well-investigated. However, the impact of DENV infection on B cell subsets and their antibody-independent functions are not well-documented. Through this study, we aimed to define the distribution of B cell subsets in the acute phase of DENV infection and characterize the effect of DENV infection on B cell functions such as differentiation into memory and plasma cells and cytokine production. In our cohort of Cambodian children, we observed decreased percentages of CD24^hiCD38^hi B cells and CD27^- naïve B cells within the

SUBMITTER: Upasani V 

PROVIDER: S-EPMC6834554 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature