Production of reactive species in alginate hydrogels for cold atmospheric plasma-based therapies.

ABSTRACT: In the last years, great advances have been made in therapies based in cold atmospheric plasmas (CAP). CAP generate reactive oxygen and nitrogen species (RONS) which can be transferred to liquids. These CAP activated liquids display the same biological efficacy (i.e. on killing cancer cells) as CAP themselves, opening the door for minimally invasive therapies. However, injection of a liquid in the body results in fast diffusion due to extracellular fluids and blood flow. Therefore, the development of efficient vehicles which allow local confinement and delivery of RONS to the diseased site is a fundamental requirement. In this work, we investigate the generation of RONS (H₂O₂, NO₂^-, short-lived RONS) in alginate hydrogels by comparing two atmosph

SUBMITTER: Labay C 

PROVIDER: S-EPMC6834627 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature