Unknown

Dataset Information

0

Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction.

ABSTRACT: No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of KUS121 in a porcine ischemia and reperfusion injury model. These findings confirmed that KUS121 is a promising novel therapeutic agent for myocardial infarction in conjunction with primary percutaneous coronary intervention.

SUBMITTER: Ide Y 

PROVIDER: S-EPMC6834964 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of  ...[more]

Similar Datasets

Unknown Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration.
| S-EPMC4977562 | biostudies-literature
Unknown A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis.
| S-EPMC7695735 | biostudies-literature
Unknown KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress.
| S-EPMC5357950 | biostudies-literature
Unknown The effect of KUS121, a novel VCP modulator, against ischemic injury in random pattern flaps.
| S-EPMC11671021 | biostudies-literature
Unknown A novel micropeptide, Slitharin, exerts cardioprotective effects in myocardial infarction.
| S-EPMC11374934 | biostudies-literature
Unknown Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction.
| S-EPMC9139780 | biostudies-literature
Unknown Cardioprotective Effects of LCZ696 (Sacubitril/Valsartan) After Experimental Acute Myocardial Infarction.
| S-EPMC6059351 | biostudies-literature
Unknown Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction.
| S-EPMC2823907 | biostudies-other
Unknown Cardioprotective Effects of Rivaroxaban on Cardiac Remodeling After Experimental Myocardial Infarction in Mice.
| S-EPMC7921351 | biostudies-literature
Unknown Multiparametric Immunoimaging Maps Inflammatory Signatures in Murine Myocardial Infarction Models.
| S-EPMC10401290 | biostudies-literature