Ontology highlight
ABSTRACT:
SUBMITTER: Ide Y
PROVIDER: S-EPMC6834964 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Ide Yuya Y Horie Takahiro T Saito Naritatsu N Watanabe Shin S Otani Chiharu C Miyasaka Yui Y Kuwabara Yasuhide Y Nishino Tomohiro T Nakao Tetsushi T Nishiga Masataka M Nishi Hitoo H Nakashima Yasuhiro Y Nakazeki Fumiko F Koyama Satoshi S Kimura Masahiro M Tsuji Shuhei S Rodriguez Randolph Ruiz RR Xu Sijia S Yamasaki Tomohiro T Watanabe Toshimitsu T Yamamoto Masamichi M Yanagita Motoko M Kimura Takeshi T Kakizuka Akira A Ono Koh K
JACC. Basic to translational science 20191028 6
No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of ...[more]