Thermosensitive Nanocomposite Hydrogels for Intravitreal Delivery of Cefuroxime.

ABSTRACT: Endophthalmitis is a rare, but serious, intravitreal inflammatory disorder that can arise after cataract surgery. The intracameral injection of 1 mg cefuroxime (CEF) followed by three-times daily antibiotic topical administration for a week is generally recognized as the routine method of prophylaxis after cataract surgery. This procedure is controversial because of both the low efficacy and the low adherence to therapy by elderly patients. A unique slow release antibiotic intravitreal injection could solve these problems. The objective of the present study was to design ophthalmic nanocomposite delivery systems based on in situ gelling formulations that undergo sol-to-gel transition upon change in temperature to prolong the effect of CEF. Oil in water (O/W) microemulsion (µE) and solid li

SUBMITTER: Sapino S 

PROVIDER: S-EPMC6835325 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature