Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of <i>Bifidobacterium longum</i>, AHCC^® and Azithromycin in Healthy Individuals.

ABSTRACT: The probiotic Bifidus BB536 (BB536), which contains Bifidobacterium longum, has been shown to have enhanced probiotic effects when given together with a standardized extract of cultured Lentinula edodes mycelia (AHCC^®, Amino Up Co. Ltd., Sapporo, Japan). BB536 and AHCC^® may modulate T cell and dendritic cell (DC) phenotypes, and cytokine profiles to favour anti-inflammatory responses following antibiotic ingestion. We tested the hypothesis that orally administered BB536 and/or AHCC^®, results in modulation of immune effector cells with polarisation towards anti-inflammatory responses following antibiotic usage. Forty healthy male volunteers divided into 4 equal groups were randomised to receive either placebo, BB536, AHCC^® or a combi

SUBMITTER: Chowdhury AH 

PROVIDER: S-EPMC6835407 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature