Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus.

ABSTRACT: Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus, one aspyrone-related polyketide aspilactonol G (2), one meroterpenoid 12-epi-aspertetranone D (4), two drimane derivatives (7,9), together with five known metabolites (1,3,5,6,8,10). The structures of compounds 1-10 were established by NMR and MS techniques. The absolute stereoconfigurations of compounds 1 and 2 were determined by a modified Mosher's method. The absolute configurations of compounds 4 and 7 were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds 7 and 8 exhibited

SUBMITTER: Yurchenko AN 

PROVIDER: S-EPMC6835654 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature