Short Chain Fatty Acids and Fecal Microbiota Abundance in Humans with Obesity: A Systematic Review and Meta-Analysis.

ABSTRACT: There have been mixed results regarding the relationship among short chain fatty acids (SCFAs), microbiota, and obesity in human studies. We selected studies that provided data on SCFA levels or fecal microbiota abundance in obese and nonobese individuals and then combined the published estimates using a random-effects meta-analysis. Obese individuals had significantly higher fecal concentrations of acetate (SMD (standardized mean differences) = 0.87, 95% CI (confidence interva) = 0.24-1.50, I2 (I-squared) = 88.5), propionate (SMD = 0.86, 95% CI = 0.35-1.36, I2 = 82.3%), and butyrate (SMD = 0.78, 95% CI = 0.29-1.27, I2 = 81.7%) than nonobese controls. The subgroup analyses showed no evidence of heterogeneity among obese individuals with a BMI >30 kg/m2 (I2 = 0.0%). At the phylum level, the

SUBMITTER: Kim KN 

PROVIDER: S-EPMC6835694 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature