Hypnotic Effects of Lactobacillus fermentum PS150^TM on Pentobarbital-Induced Sleep in Mice.

ABSTRACT: The bidirectional communication between the gastrointestinal tract and the central nervous system appears to be functionally linked to the intestinal microbiome, namely the microbiome-gut-brain axis (MGBA). Probiotics with health benefits on psychiatric or neurological illnesses are generally called psychobiotics, and some of them may also be able to improve sleep by targeting the MGBA. This study aimed to investigate the effects of a psychobiotic strain, Lactobacillus fermentum PS150^TM (PS150^TM), on sleep improvement by using a pentobarbital-induced sleep mouse model. Compared with the vehicle control group, the oral administration of PS150^TM, but not the other L. fermentum strains, significantly decreased the sleep latency and increased the

SUBMITTER: Lin A 

PROVIDER: S-EPMC6836230 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature