Association of high sensitive C-reactive protein with coronary heart disease: a Mendelian randomization study.

ABSTRACT:

Objectives

Whether high sensitivity C-reactive protein (hs-CRP) has a causal effect on coronary heart disease (CHD) is unclear. This study investigated the causal effect of hs-CRP on CHD risk using Mendelian Randomization (MR) analysis.

Methods

A total of 3802 subjects were recruited in the follow-up study. Linear regression model was used to evaluate the relationship between CRP polymorphisms and hs-CRP. Survival receiver operator characteristic curve method was used to explore the cut-off of hs-CRP on CHD incidence. Cox regression model was applied to detect the association of hs-CRP with CHD by calculating the hazard ratio (HR) and 95% confidence interval (CI). Rs1205 and rs876537 in CRP were selected as instrumental variables in MR analysis.

Results

During a media

SUBMITTER: Zhuang Q 

PROVIDER: S-EPMC6836320 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature