Pleiotropic regulation of a glucose-specific PTS in Clostridium acetobutylicum for high-efficient butanol production from corn stover without detoxification.

ABSTRACT:

Background

Corn stover (CS) is evaluated as the most favorable candidate feedstock for butanol production via microbial acetone-butanol-ethanol (ABE) fermentation by Clostridium acetobutylicum. By independent acid pretreatment and enzymatic hydrolysis, fermentable sugars (mainly glucose and xylose) were released, of which glucose was naturally utilized as the most preferred carbon source by C. acetobutylicum. However, the ABE fermentation using corn stover hydrolysate (CSH) without detoxification is typically limited to poor sugars utilization, butanol production and productivity. In the presence of pretreatment-derived inhibitors, the intracellular ATP and NADH, as important factors involved in cell growth, solventogenesis initiation and stress response, are exceedin

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6836401 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature