In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting.

ABSTRACT:

Background

For decades, bioprospecting has proven to be useful for the identification of compounds with pharmacological potential. Considering the great diversity of Colombian plants and the serious worldwide public health problem of dengue-a disease caused by the dengue virus (DENV)-in the present study, we evaluated the anti-DENV effects of 12 ethanolic extracts derived from plants collected in the Colombian Caribbean coast, and 5 fractions and 5 compounds derived from Psidium guajava.

Methods

The cytotoxicity and antiviral effect of 12 ethanolic extracts derived from plants collected in the Colombian Caribbean coast was evaluated in epithelial VERO cells. Five fractions were obtained by open column chromatography from the ethanolic extract with the highest selectivity ind

SUBMITTER: Trujillo-Correa AI 

PROVIDER: S-EPMC6836419 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature