Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma.

ABSTRACT: BACKGROUND:MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associated with aberrant MYC function in various cancers, including brain tumors such as glioblastoma. However, the role of PRMT5 and its association with MYC in medulloblastoma have not been explored. Here, we report the role of PRMT5 as a novel regulator of MYC and implicate PRMT5 as a potential therapeutic target in MYC-driven medulloblastoma. METHODS:Expression and association between PRMT5 and MYC in primary medulloblastoma tumors were investigated using publicly available databases. Expression levels of PRMT5 protein were also examined using medulloblastoma cell lines and prim

SUBMITTER: Chaturvedi NK 

PROVIDER: S-EPMC6836472 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature