Impact of metformin use among tuberculosis close contacts with diabetes mellitus in a nationwide cohort study.

ABSTRACT: BACKGROUND:The protective effect of metformin against active tuberculosis (TB) among TB close contacts is unknown. METHODS:TB close contacts with diabetes mellitus (DM) and normal renal function were selected from the National Health Insurance Research Database of Taiwan. Metformin users were patients who received ≥90 cumulative defined daily doses within 1 year before the index date. For each metformin user, a propensity-score matched metformin nonuser and an age- and sex-matched healthy TB close contact were selected. The outcome was incident TB, identified using previously validated diagnostic criteria. Independent predictors were investigated using stratified Cox regression analysis. Interaction analysis was also performed. RESULTS:A total of 5846 TB close contacts who were metformin u

SUBMITTER: Lee MC 

PROVIDER: S-EPMC6836500 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature