Prediction of Time to Hormonal Treatment Failure in Metastatic Castration-Sensitive Prostate Cancer with ¹⁸F-FDG PET/CT.

ABSTRACT: The aim of this prospective investigation was to assess the association of ¹⁸F-FDG PET/CT with time to hormonal treatment failure (THTF) in men with metastatic castration-sensitive prostate cancer. Methods: 76 men with metastatic castration-sensitive prostate cancer recruited from 2005 to 2011 underwent ¹⁸F-FDG PET/CT and were followed prospectively for THTF, defined as treatment change to chemotherapy or death. Patients who had not switched to chemotherapy were censored at the last follow-up date (median of 36 mo; range, 12-108 mo). Cox regression analyses were performed to examine the association between PET/CT measurements: sum of SUV_max, maximum SUV_max, and average SUV_max for up to 10 of the most active lesions and THTF. Sur

SUBMITTER: Jadvar H 

PROVIDER: S-EPMC6836859 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature