Progressive Tau Accumulation in Alzheimer Disease: 2-Year Follow-up Study.

ABSTRACT: Tau PET enables in vivo visualization and quantitation of tau accumulation in Alzheimer disease (AD). In cross-sectional tau PET studies, tau burden reflects disease severity and phenotypic variation. We investigated longitudinal changes in cortical tau accumulation and their association with cognitive decline in patients with AD. Methods: We enrolled 107 participants (45 amyloid-β-negative cognitively unimpaired [CU-], 7 amyloid-β-positive cognitively unimpaired [CU+], 31 with prodromal AD [mild cognitive impairment; MCI+], and 24 with AD dementia [DEM+]) who completed 2 baseline PET scans (¹⁸F-flortaucipir and ¹⁸F-florbetaben), MRI, and neuropsychologic tests. All participants underwent the same assessments after 2 y. After correcting for partial-volume effec

SUBMITTER: Cho H 

PROVIDER: S-EPMC6836867 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature