Efficacy of high doses of penicillin versus amoxicillin in the treatment of uncomplicated community acquired pneumonia in adults. A non-inferiority controlled clinical trial.

ABSTRACT: INTRODUCTION:Community-acquired pneumonia (CAP) is treated with penicillin in some northern European countries. OBJECTIVES:To evaluate whether high-dose penicillin V is as effective as high-dose amoxicillin for the treatment of non-severe CAP. DESIGN:Multicentre, parallel, double-blind, controlled, randomized clinical trial. SETTING:31 primary care centers in Spain. PARTICIPANTS:Patients from 18 to 75 years of age with no significant associated comorbidity and with symptoms of lower respiratory tract infection and radiological confirmation of CAP were randomized to receive either penicillin V 1.6 million units, or amoxicillin 1000mg three times per day for 10 days. MAIN MEASUREMENTS:The main outcome was clinical cure at 14 days, and the primary hypothesis was that penicillin V would be non

SUBMITTER: Llor C 

PROVIDER: S-EPMC6836912 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature