Reactive oxygen species-triggered off-on fluorescence donor for imaging hydrogen sulfide delivery in living cells.

ABSTRACT: Hydrogen sulfide (H2S), an important gasotransmitter, can mediate a variety of pathophysiological processes, and H2S-based donors have been intensively explored for the therapy of cardiovascular injury, nerve damage and intestinal disorders. However, most of the H2S donors are not capable of simultaneously real-time tracking intracellular H2S delivery, which limits their biological application for elucidating the specific function of H2S. Herein we develop the first reactive oxygen species (ROS)-triggered off-on fluorescence H2S donor (NAB) by incorporating ROS-responsive arylboronate into a fluorophore through thiocarbamate. The donor NAB can release carbonyl sulfide (COS) and the fluorophore with a fluorescence off-on response via a ROS-triggered self-immolative reaction, and then COS is

SUBMITTER: Hu Y 

PROVIDER: S-EPMC6836935 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature