Formation of neural networks with structural and functional features consistent with small-world network topology on surface-grafted polymer particles.

ABSTRACT: In vitro electrophysiological investigation of neural activity at a network level holds tremendous potential for elucidating underlying features of brain function (and dysfunction). In standard neural network modelling systems, however, the fundamental three-dimensional (3D) character of the brain is a largely disregarded feature. This widely applied neuroscientific strategy affects several aspects of the structure-function relationships of the resulting networks, altering network connectivity and topology, ultimately reducing the translatability of the results obtained. As these model systems increase in popularity, it becomes imperative that they capture, as accurately as possible, fundamental features of neural networks in the brain, such as small-worldness. In this report, we co

SUBMITTER: Valderhaug VD 

PROVIDER: S-EPMC6837210 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature