Ontology highlight
ABSTRACT:
SUBMITTER: Quiroz JA
PROVIDER: S-EPMC6837291 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
PLoS pathogens 20191107 11
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes persistent arthritis in a subset of human patients. We report the isolation and functional characterization of monoclonal antibodies (mAbs) from two patients infected with CHIKV in the Dominican Republic. Single B cell sorting yielded a panel of 46 human mAbs of diverse germline lineages that targeted epitopes within the E1 or E2 glycoproteins. MAbs that recognized either E1 or E2 proteins exhibited neutralizing activity. ...[more]