Involvement of extracellular vesicles in the macrophage-tumor cell communication in head and neck squamous cell carcinoma.

ABSTRACT: BACKGROUND:Exosomes are cell-derived vesicles that mediate cellular communication in health and multiple diseases, including cancer. However, its role in head and neck cancer has been poorly defined. Here, we investigated the relevance of exosomes in the signaling between larynx cancer cells and macrophages. METHODS:Exosomes from THP1 macrophages and BICR18 cells (a larynx squamous cell carcinoma cell line) were purified and their role in the cancer cell migration, macrophage phenotype and immunosuppressive activity was evaluated. The activation of STAT3 signal transduction in macrophages in response to exosomes obtained from cancer cells was also evaluated. RESULTS:Macrophages foster the cancer cell migration and this effect is mediated by exosome signaling. On the other hand, exosomes al

SUBMITTER: Bellmunt AM 

PROVIDER: S-EPMC6837305 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature