Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses' Health Study.

ABSTRACT:

Objective

To examine the interaction between APOE genotypes and both treated and untreated hypertension on cognitive function in an updated analysis of Nurses' Health Study (NHS) data.

Design

At baseline (1995-2001) and 3 biennial follow-up assessments over ~6 years, cognitive function was assessed.

Setting and participants

8300 NHS participants aged 70+ years underwent a cognitive battery, which comprised 6 tests including the Telephone Interview for Cognitive Status (TICS) and tests of verbal memory, category fluency, and working memory.

Measures

We estimated the mean differences in average cognitive scores across up to 4 assessments using multiple linear regression. We also tested for interaction between APOE e4 allele carrier status and hypertension overall

SUBMITTER: Kim IY 

PROVIDER: S-EPMC6837309 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature