LINE-1 methylation levels, a biomarker of weight loss in obese subjects, are influenced by dietary antioxidant capacity.

ABSTRACT:

Objectives

Epigenetic markers, and in particular DNA methylation, have come to the fore as new tools in the personalization of the treatment of obesity and its comorbidities. The objectives of the current investigation were to identify epigenetic biomarkers that might be predictive of response to a weight-loss intervention, and to better understand the influence of certain nutrients (particularly antioxidants) on the epigenome.

Methods

Global DNA (LINE-1) methylation levels were assessed in peripheral blood mononuclear cells (PBMCs) from 96 obese volunteers of the Metabolic Syndrome Reduction in Navarra study, using a methylation-sensitive high resolution melting approach after bisulfite modification.

Results

Baseline LINE-1 DNA methylation levels were significantly h

SUBMITTER: Garcia-Lacarte M 

PROVIDER: S-EPMC6837392 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature