Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures.

ABSTRACT: Epilepsy is a significant contributor to worldwide disability. In epilepsy, disability can be broadly divided into two components: ictal (pertaining to the burden of unpredictable seizures and associated medical complications including death) and interictal (pertaining to more pervasive debilitating changes in cognitive and emotional behavior). In this study, we objectively and noninvasively appraise aspects of ictal and interictal behavior in mice using instrumented home-cage chambers designed to assay kinematic and appetitive behavioral measures. Through daily intraperitoneal injections of the chemoconvulsant pentylenetetrazole (PTZ) applied to C57BL/6J mice, we coordinately measure how "behavioral severity" (complex dynamic changes in movement and sheltering behavior) and convulsive sev

SUBMITTER: Jankovic MJ 

PROVIDER: S-EPMC6837443 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature