Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration.

ABSTRACT: The somatic co-evolution of tumors and the cellular immune responses that combat them drives the diversity of immune-tumor interactions. This includes tumor mutations that generate neo-antigenic epitopes that elicit cytotoxic T-cell activity and subsequent pressure to select for genetic loss of antigen presentation. Most studies have focused on how tumor missense mutations can drive tumor immunity, but frameshift mutations have the potential to create far greater antigenic diversity. However, expression of this antigenic diversity is potentially regulated by Nonsense Mediated Decay (NMD) and NMD has been shown to be of variable efficiency in cancers. Here we studied how mutational changes influence global NMD and cytolytic immune responses. Using TCGA datasets, we derived novel patient-lev

SUBMITTER: Zhao B 

PROVIDER: S-EPMC6837539 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature