Seasonal influenza: Modelling approaches to capture immunity propagation.

ABSTRACT: Seasonal influenza poses serious problems for global public health, being a significant contributor to morbidity and mortality. In England, there has been a long-standing national vaccination programme, with vaccination of at-risk groups and children offering partial protection against infection. Transmission models have been a fundamental component of analysis, informing the efficient use of limited resources. However, these models generally treat each season and each strain circulating within that season in isolation. Here, we amalgamate multiple data sources to calibrate a susceptible-latent-infected-recovered type transmission model for seasonal influenza, incorporating the four main strains and mechanisms linking prior season epidemiological outcomes to immunity at the beginning of th

SUBMITTER: Hill EM 

PROVIDER: S-EPMC6837557 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature