Model-driven discovery of calcium-related protein-phosphatase inhibition in plant guard cell signaling.

ABSTRACT: The plant hormone abscisic acid (ABA) promotes stomatal closure via multifarious cellular signaling cascades. Our previous comprehensive reconstruction of the stomatal closure network resulted in an 81-node network with 153 edges. Discrete dynamic modeling utilizing this network reproduced over 75% of experimental observations but a few experimentally supported results were not recapitulated. Here we identify predictions that improve the agreement between model and experiment. We performed dynamics-preserving network reduction, resulting in a condensed 49 node and 113 edge stomatal closure network that preserved all dynamics-determining network motifs and reproduced the predictions of the original model. We then utilized the reduced network to explore cases in which experimental activation

SUBMITTER: Maheshwari P 

PROVIDER: S-EPMC6837631 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature