Transcriptional Network Analysis Implicates Altered Hepatic Immune Function in NASH development and resolution.

ABSTRACT: Progression of fatty liver to non-alcoholic steatohepatitis (NASH) is a rapidly growing health problem. Presence of inflammatory infiltrates in the liver and hepatocyte damage distinguish NASH from simple steatosis. However, the underlying molecular mechanisms involved in the development of NASH remain to be fully understood. Here we perform transcriptional and immune profiling of NASH patients before and after lifestyle intervention (LSI). Analysis of liver microarray data from a cohort of patients with histologically assessed NAFLD reveals a hepatic gene signature, which is associated with NASH and is sensitive to regression of NASH activity upon LSI independently of body weight loss. Enrichment analysis reveals the presence of immune-associated genes linked to inflammatory responses, an

SUBMITTER: Haas JT 

PROVIDER: S-EPMC6837876 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature