Nonsteroidal anti-inflammatory drug use and breast cancer risk in a European prospective cohort study.

ABSTRACT: Experimental studies have shown a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer development. However, results from epidemiological cohort studies are less consistent. Our objective was to assess the association between NSAID use and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Self-reported information on NSAID use at baseline has been collected in five EPIC countries. Multivariable Cox regression models were used to estimate hazard ratios for the association of NSAID use with breast cancer incidence with adjustment for potential confounders. We also assessed effect modification by breast cancer risk factors and examined

SUBMITTER: Cairat M 

PROVIDER: S-EPMC6837880 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature