In vivo biocompatibility and immunogenicity of metal-phenolic gelation.

ABSTRACT: In vivo forming hydrogels are of interest for diverse biomedical applications due to their ease-of-use and minimal invasiveness and therefore high translational potential. Supramolecular hydrogels that can be assembled using metal-phenolic coordination of naturally occurring polyphenols and group IV metal ions (e.g. Ti^IV or Zr^IV) provide a versatile and robust platform for engineering such materials. However, the in situ formation and in vivo response to this new class of materials has not yet been reported. Here, we demonstrate that metal-phenolic supramolecular gelation occurs successfully in vivo and we investigate the host response to the material over 14 weeks. The Ti^IV-tannic acid materials form stable gels that are well-to

SUBMITTER: Bjornmalm M 

PROVIDER: S-EPMC6837883 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature