Somatic mutations and clonal dynamics in healthy and cirrhotic human liver.

ABSTRACT: The most common causes of chronic liver disease are excess alcohol intake, viral hepatitis and non-alcoholic fatty liver disease, with the clinical spectrum ranging in severity from hepatic inflammation to cirrhosis, liver failure or hepatocellular carcinoma (HCC). The genome of HCC exhibits diverse mutational signatures, resulting in recurrent mutations across more than 30 cancer genes^1-7. Stem cells from normal livers have a low mutational burden and limited diversity of signatures⁸, which suggests that the complexity of HCC arises during the progression to chronic liver disease and subsequent malignant transformation. Here, by sequencing whole genomes of 482 microdissections of 100-500 hepatocytes from 5 normal and 9 cirrhotic livers, we show that cirrhotic liver h

SUBMITTER: Brunner SF 

PROVIDER: S-EPMC6837891 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature