Low versus high pulse oxygen saturation directed oxygen therapy in critically ill patients: a randomized controlled pilot study.

ABSTRACT:

Background

Data on the safety and feasibility of pulse oxygen saturation (SpO₂) directed oxygen therapy in mainland China are scarce. The aim of this pilot study was to test the feasibility of SpO₂ directed oxygen therapy and to calculate sample size base on differences in 28-day mortality rates for a large sample-sized randomized trial.

Methods

This prospective pilot study enrolled 214 adult patients with an expected intensive care unit (ICU) stay of more than 72 hours. Patients were randomized into a low SpO₂ group (SpO₂ 90-95%) or high SpO₂ group (SpO₂ 96-100%). The primary outcome was 28-day mortality.

Results

One hundred patients were included in the low SpO₂ group, and 114 patients were

SUBMITTER: Yang X 

PROVIDER: S-EPMC6837987 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature